Generic name: Avatrombopag Maleate Tablets
Brand name: Trombo
Composition:
Each tablet contains:
Avatrombopag Maleate……………………………………20mg
Indications:
Trombo is a thrombopoietin receptor agonist indicated for the treatment of:
• Thrombocytopenia in adults with chronic liver disease who are planning surgery.
• Thrombocytopenia in adult patients with chronic immune thrombocytopenia who have had an inadequate response to prior therapy.
Dosage:
• Take tablets orally with food.
• Chronic liver disease: Dosage is based on platelet count (see table below) Dosing should begin 10-13 days prior to plan procedure. The patient should undergo their procedure 5-8 days after last dose of Trombo.
|
Platelet count (_x 109 /L) |
Once-daily dose | Duration of dosing |
| ≤40 | 60mg (three 20mg tablets) | 5 days |
| ≥40 to ≤50 | 40mg (two 20mg tablets) | 5 days |
• Chronic Immune Thrombocytopenia: start dosing at 20mg (1 tablet) once daily. Adjust dosing or dosing frequency rate to maintain a platelet count greater than or equal to 50 x 109 / L. Do not exceed 40mg a day or follow a physician’s advice.
Contraindications:
• Pregnant and Lactating women.
Warnings:
• Thrombotic/ thromboembolic complications: Trombo is a thrombopoietin receptor agonist that has been associated with thrombotic and thromboembolic complications in patients with chronic liver disease or chronic immune thrombocytopenia.
• Monitor platelet counts. Look for signs and symptoms of thromboembolic events and initiate treatment promptly.
• Using this drug during pregnancy may harm the fetus, do not use while breastfeeding.
Adverse Effects:
In patients with chronic liver disease, the most common adverse reactions (≥3%) were pyrexia, abdominal pain, nausea, headache, fatigue and peripheral edema.
Dosage form: White tablet.
Expiry date: 24 months after date of manufacture.
Packaging:
• 10 tablets/ blister pack, 3 blisters/box.
Storage:
• Store in the original container.
• Store under 25ᵒC, protected from moisture and direct sunlight away from children.
DISCLAIMER
The information on this website about our medications is intended for general educational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking care because of something you have read on this website.
For your safety:
Do not self-diagnose or treat any medical condition based solely on the information on this website. If you have any questions or concerns about a medication, please talk to your doctor or pharmacist.
