Brand name: ALIENTRECTINIB
Composition:
Each tablet contains:
Entrectinib………………………………………..100mg
Indications:
- Adult patients with ROS1-positive metastatic non-small cell lung cancer (NSCLC).
- Patients 1 month and older with solid tumors who meet the following conditions:
- Have a neurotrophic receptor tyrosine kinase (NTRK) fusion-positive solid tumors.
- Patients with locally advanced, metastatic disease, or if surgical resection may lead to serious complications.
- Have no satisfactory standard therapy or that have progressed following treatment.
Dosage:
- Adult: 600mg, once a day.
- Patients 1 month to 6 months – 250mg/m2
- Children over 6 months old: 300mg/m2, once a day, See table:
Body surface area(BSA) | Administer once daily |
1.11-1.50m2 | 400mg |
≥1.51m2 | 600mg |
- The product can be taken with or without food.
- Swallow capsules whole. Do not crush or chew the capsules.
- Continue taking the product, until disease progression or until unacceptable toxicity.
Contraindications:
- None.
Warnings:
- Avoid coadministration with moderate or strong CYP3A inhibitors. If coadministration cannot be avoided, reduce the ALIENTRECTINIB dose and limit coadministration to 14 days or less.
- Avoid administration with drugs that prolong QTc interval.
- Pregnant and lactating women should use with caution.
- Patients with congestive heart failure and/or skeletal fractures should use with caution.
- Elevated risk of central nervous system effects, vision disorders, hepatotoxicity or hyperuricemia.
Adverse Effects:
Fatigue, constipation, dysgeusia, edema, dizziness, diarrhea, nausea, dysesthesia, dyspnea, myalgia, cognitive impairment, increased weight, cough, vomiting, pyrexia, arthralgia, and vision disorders.
Dosage form: Yellow opaque HPMC capsule.
Expiry date: 24 months after date of manufacture.
Packaging:
- 60 capsules/bottle.
Storage:
- Protected from light, sealed in original packaging, and stored at 20℃- 25℃.
- Keep out of reach of children.
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Do not self-diagnose or treat any medical condition based solely on the information on this website. If you have any questions or concerns about a medication, please talk to your doctor or pharmacist.